Bare Health

Wednesday, 28 January 2015

Hyaluronic Acid & Syno-Vital - What is it and what are its benefits?

Good news for your joints, skin, eyes & mucous membranes!

So what is Hyaluronic Acid (HA)?

HA is naturally found throughout your body—in your skin, your eyes’ vitreous fluid, and your joints’ synovial fluid. Its roles are numerous, from facilitating cell signalling and supporting normal wound repair, to acting as a lubricant, antioxidant and shock-absorbing cushion for your joints.1 But unfortunately, your body’s natural HA stores take a dip over time… setting you up for all the tell-tale signs of aging, from intermittently stiff joints to crow’s feet, as a consequence.
Luckily, the news isn’t all bad—because while your body will inevitably lose HA as you age, research shows that daily supplementation may be a simple yet effective way to make up for it.
For example, trials indicate that oral HA can also help support healthy joints—yielding significant improvements over placebo in measures of joint comfort after just eight weeks of supplementation, and offering beneficial support in older individuals’ efforts to stay flexible and maintain optimal joint mobility.2-5 The inflammation-balancing, free radical-fighting, cartilage-supportive benefits of HA continue to be confirmed, with research suggesting that this substance’s interaction with specific CD44 receptors is responsible for its rejuvenating and protective effect on cartilage cells.6-8
As an added benefit, HA is a demonstrated wrinkle-fighter, too. Declines in HA are directly linked to saggy, drooping skin—but laboratory studies show that supplementation can help to renew and rejuvenate your skin from the inside out, by balancing a number of inflammatory mediators linked to collagen degradation.9-12
Eye health is another area that can suffer from natural declines in HA—but as with your joints and skin, high molecular weight HA can come to your rescue. Studies show that HA is able to promote the health of your eyes in response to the effects of the sun’s UV rays, while keeping them moist and easing the discomfort that comes with long hours in front of the computer.13-17
Last, but not least, emerging research indicates that HA may keep your mouth and gums in tip-top shape, too. Studies indicate that it can facilitate oral tissue health and support and strengthen mucous membranes, while keeping your mouth moist—all critical factors in lasting dental health.18-23
It’s hard to believe that a single compound could be responsible for smooth skin, healthy joints and eyes, and good dental health. But research shows that supplementing with HA is one way to address all of these common factors associated with aging… meaning naturally occurring hyaluronic acid (HA) is the secret to youth and health.
Supplementing orally with Hyaluronan is reported to be the best method of delivery to the body, however, 

not all Hyaluronan supplements are the same...

There are many Hyaluronic Acid products available now on the market.
A review from the Journal of Applied Nutrition examines the different kinds of HA available and talks about their effectiveness:
“..dietary supplements containing HA are not equivalent due to the inherent properties of the three major types of HA commercially available as dietary supplement materials. Consumers and health care professionals need to be aware of the different types of HA and their very large differences in properties (even before ingestion). One source, hydrolysed chicken sternal cartilage, is clearly unlike native HA, does not match the biological properties of native HA, and consequently should not be represented as HA to consumers on product labels…”
The lesson to take on board then is that not all Hyaluronic Acid is created equal. Syno-vital® is a patented Hyaluronan supplement high in molecular weight HA, measuring up to approximately 2.4-3 million Daltons! It also has proven bio availabilty and absorption. Click here to read the entire review (pdf)
Voted best Vitamin,Mineral Supplement of the year 2012 Synovital Hyaluronan is a natural liquid form of hyaluronic acid that has been found to help increase mobility and reduce pain and inflammation in patients with osteoarthritis. With its high lubrication and cushioning effect it helps to reduce friction and resist compression, allowing joints to bear weight and withstand tension. The Hyaluronic acid in Syno-Vital works in several ways:
  • it helps to restore synovital fluid for improved mobility
  • it prevents further degradation of joint tissues
  • it has an anti inflammatory, analgesic effect
  • It can also provide movement where glucosamine and chondroitin have failed to do so.
According to research Hyaluronic acid taken daily helps to rebuild the 'pillow' of fluid that cushions the joints for upto 97% of people who try it!


For a limited time only buy Syno-Vital and get a Hydra-Vital Skin Serum (worth £20.99) absolutely FREE!! Available in store & online at

Hydra-Vital Serum is a professional strength Hyaluronic acid serum which acts as a powerful moisturising serum, it holds upto 1,000 times its weight in water and is gentle enough for even the most sensitive of skin types. 

Use daily to help raise the skins moisture level to fill in furrows, plump up tissues and tone down age lines!


1. Volpi N, Schiller J, Stern R, Soltés L. Role, metabolism, chemical modifications and applications of hyaluronan. Curr Med Chem. 2009;16(14):1718-1745.
2. Sun SF, Chou YJ, Hsu CW, Chen WL. Hyaluronic acid as a treatment for ankle osteoarthritis. Curr Rev Musculoskelet Med. 2009 Mar 13.
3. Kalman DS, Heimer M, Valdeon A, Schwartz H, Sheldon E. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutr J. 2008 Jan 21;7:3.
4. Adams ME, Lussier AJ, Peyron JG. A risk-benefit assessment of injections of hyaluronan and its derivatives in the treatment of knee osteoarthritis. Drug Saf. 2000;23:115-130.
5. Strauss EJ, Hart JA, Miller MD, Altman RD, Rosen JE. Hyaluronic Acid Viscosupplementation and Osteoarthritis: Current Uses and Future Directions. Am J Sports Med. 2009 Feb 3.
6. Akmal M, Singh A, Anand A, et al. The effects of hyaluronic acid on articular chondrocytes. J Bone Joint Surg Br. 2005;87:1143-1149.
7. Grishko V, Xu M, Ho R, et al. Effects of hyaluronic acid on mitochondrial function and mitochondria-driven apoptosis following oxidative stress in human chondrocytes. J Biol Chem. 2009 Apr 3;284(14):9132-9139.
8. Matsuno H, Nakamura H, Katayama K, et al. Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis. Biosci Biotechnol Biochem. 2009 Feb;73(2):288-292.
9. Ghersetich I, Lotti T, Campanile G, Grappone C, Dini G. Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatol. 1994 Feb;33(2):119-122.
10. Greco RM, Iocono JA, Ehrlich HP. Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. J Cell Physiol. 1998 Dec;177(3):465-473.
11. Karna E, Miltyk W, Palka JA, Jarzabek K, Wolczynski S. Hyaluronic acid counteracts interleukin-1-induced inhibition of collagen biosynthesis in cultured human chondrocytes. Pharmacol Res. 2006 Oct;54(4):275-281.
12. Nawrat P, Surazynski A, Karna E, Palka JA. The effect of hyaluronic acid on interleukin-1-induced deregulation of collagen metabolism in cultured human skin fibroblasts. Pharmacol Res. 2005 May;51(5):473-477.
13. Tanaka M, Masuko-Hongo K, Kato T, Nishioka K, Nakamura H. Suppressive effects of hyaluronan on MMP-1 and RANTES production from chondrocytes. Rheumatol Int. 2006 Jan;26(3):185-190.
14. Tate DJ Jr, Oliver PD, Miceli MV, Stern R, Shuster S, Newsome DA. Age-dependent change in the hyaluronic acid content of the human chorioretinal complex. Arch Ophthalmol. 1993 Jul;111(7):963-967.
15. Pauloin T, Dutot M, Joly F, Warnet JM, Rat P. High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells. Mol Vis. 2009;15:577-583.
16. Johnson ME, Murphy PJ, Boulton M. Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eye. Graefes Arch Clin Exp Ophthalmol. 2006 Jan;244(1):109-112.
17. Brignole F, Pisella PJ, Dupas B, Baeyens V, Baudouin C. Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. Graefes Arch Clin Exp Ophthalmol. 2005 Jun;243(6):531-538.
18. Acosta MC, Gallar J, Belmonte C. The influence of eye solutions on blinking and ocular comfort at rest and during work at video display terminals. Exp Eye Res. 1999 Jun;68(6):663-669.
19. Sukumar S, Drízhal I. Hyaluronic acid and periodontitis. Acta Medica (Hradec Kralove). 2007;50(4):225-228.
20. Pistorius A, Martin M, Willershausen B, Rockmann P. The clinical application of hyaluronic acid in gingivitis therapy. Quintessence Int. 2005 Jul-Aug;36(7-8):531-538.
21. Lee JH, Jung JY, Bang D. The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet’s disease. J Eur Acad Dermatol Venereol. 2008 May;22(5):590-595.
22. Mendes RM, Silva GA, Lima MF, et al. Sodium hyaluronate accelerates the healing process in tooth sockets of rats. Arch Oral Biol. 2008 Dec;53(12):1155-1162.
23. Higuchi Y, Ansai T, Awano S, et al. Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls: a pilot study. Biomed Res. 2009 Feb;30(1):63-68.
24. Yuan J, Tohara H, Mikushi S, Hoshino T, Yue B, Uematsu H. The effect of “Oral Wet” for elderly people with xerostomia—the effect of oral rinse containing hialuronan. Kokubyo Gakkai Zasshi. 2005 Mar;72(1):106-110.
The Information contained within this article is intended for information purposes only. If taking prescribed medicine or undergoing any medical treatment always seek the advice of your GP or healthcare professional prior to embarking on any supplement regime.